Background: It is thought that chronic stress negatively affects immune response efficacy which in turn cause an imbalance between host and parasite leading to periodontal breakdown. The current research aimed to investigate the association between anxiety and depression with chronic periodontitis. Materials & Methods: 100 participants in this cross-sectional study, who were all over 25 years old and of both sexes, were included. The study participants were split into two groups. Subjects in Group B had clinical attachment loss of at least ≥3 mm in at least 30% of the sites inspected, and Group A samples did not meet the aforementioned requirements. Group A had 60 participants, whereas Group B had 40. One examiner conducted all of the clinical examinations. The Hospital Anxiety and Depression Scale (HADS) was the psychological tool that was used. To compare the two groups, the chi square and student t tests were used. Results: The mean depression scores in GroupA and GroupB were 6.64 ± 2.58 and 7.90 ± 2.86, respectively while the mean anxiety scores of GroupA and GroupB were 7.76 ± 3.12 and 9.07 ± 3.08, respectively (p<001). Conclusion: Within the limits of this study, it is possible to conclude that there was significant association between periodontitis and anxiety, and depression.