Background: A lumbar epidural block is a procedure commonly used to provide pain relief or anaesthesia for various conditions involving the lower abdomen and lower extremities. The present study was conducted to assess efficacy of lumbar epidural block using 0.125% bupivacaine vs 0.125% bupivacaine with ketamine. Materials & Methods: 50 ASA grade I and II patients undergoing various elective surgical procedures involving lower abdomen, pelvis, infrainguinal vascular surgeries, hip surgeries, femur surgery (surgeries requiring analgesia below T6 level) under general anaesthesia of both genders and age between 18-65 years were divided into 2 groups of 25 each. Group I received 0.125% bupivacaine 10-15 ml (as per dermatomal requirement to be blocked) and group II received bupivacaine 0.125% 10-15ml plus preservative free 1% ketamine in a dose of 0.5 mg/kg/body weight. Parameters such as weight, height, ASA grade I and II, VAS score for 24 hours and complications were recorded. Results: Both the groups were comparable (P> 0.05) in terms of demographic characteristics like age, sex, weight, height and ASA status. VAS score was similar in both the groups at 0 and 2 hours postoperatively but the difference was found statistically significant thereafter till 24 hours (p<0.05) between the two groups. Common complications were shivering, bradycardia, urinary retention and hallucinations. The difference was significant (P< 0.05). Conclusion: Lumbar epidural block using 0.125% bupivacaine with 0.5mg/kg ketamine is more efficacious for postoperative analgesia than 0.125% bupivacaine alone.