Abstract Issue

Volume 12 Issue 2 ( April- June) 2023

Original Articles

Serological and Demographic study of herpes simplex virus-2 in women with bad obstetric history
Dr. Shaik Meharunnisa Begum, Dr. ChintapalliSuryamani, Dr. Juveria Sultana, Dr. L. Jayalakshmi, Dr. R. Kondal Rao

Context: Herpes genitalis is the most common viral sexually transmitted disease worldwide. It is caused by Herpes simplex virus-2 (HSV-2) and also increasingly the Herpes simplex virus-1 (HSV-1). Maternal infections play a critical role in pregnancy wastage and their occurrence in patients with Bad Obstetric History (BOH) is a significant factor.Aim: The aim of the study is to evaluate the seroprevalence and demographic factors contributing to HSV-2 in pregnant women with BOH.Methods and Materials: A Cross sectional study was conducted on 90 pregnant women with BOH during March 2018 to August 2018. blood samples were collected after taking informed consent and tested by ELISA method to detect HSV-2 IgM and IgG antibodies. Enrolled participants history was collected in thedesigned data collection form. Results: Out of the 90 blood samples screened, the seropositivity for HSV-2 IgM was 5 (5.6%), IgG was 9 (10%) while both IgM & IgG in 2 cases (2.3%). The predominant clinical presentation responsible for BOH with HSV-2 infection were abortions in 8 cases (50%) followed by IUD 5 (31.2%) and still births in 3 cases (18.8%). Women in the age group of 25-30 years had shown the high seropositivity of HSV-2 followed by 19 - 24 years. Majority of BOH cases belonged to lower socioeconomic group 60 (66.7%). Conclusions: Association of HSV-2 seropositivity and bad obstetric outcome among low socio-economic groups suggests inclusion of TORCH profile in regular antenatal checkup along with good personal hygiene which helps in reducing the adverse fetal outcomes. Knowing the epidemiology and demographic factors are important aspects in developing new strategies and appropriate implementation for the prevention of HSV infections.

 
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