Background: The Coronavirus Disease 2019 (COVID-19) has been declared as a pandemic by the World Health Organization (WHO). Due to changes in the immunological and circulatory parameters, pregnant women are susceptible to the COVID-19 infection. Neonates born to these mothers are also at risk of infection and may have adverse outcomes due to the infection. Materials and Methods: This was a descriptive study conducted among newborns of 138 COVID-19 positive pregnant mothers admitted in the Department of Pediatrics, Niloufer hospital, Hyderabad, India from 1 May 2020 to 1 May 2021. In this study the clinical profile correlating with lab diagnosis of COVID-19 by the reverse transcription-polymerase chain reaction (RT-PCR) and outcome of babies born to COVID-19 positive mothers was evaluated in detail. Results: In the present study, total 140 babies were born to 138 mothers (137 single ton pregnancies and one triplet), out of which 5 (3.57%) were tested positive for COVID-19. About 91(65%) babies did not have any kind of risk factors, 40(30%) were admitted in Neonatal intensive care unit (NICU) and survival rate of babies was 130 (92.85%). Conclusion: Timely detection and intervention of COVID-19 will reduce obstetric complications and will improve maternal and fetal outcome.