Background:Variable levels of nutritional depletion, such as malnutrition and sarcopenia, are found in hospitalized patients’ profiles. Sarcopenia is a generalized, progressive muscle disease with a poor prognosis in various clinical settings. malnutrition is a combination of inadequate dietary intake and nutrient absorption, which results in alterations in body composition and biological function. In contrast to individuals without sarcopenia, people with sarcopenia have longer hospital stays, a higher chance of in-hospital death, and worse results following discharge. Additionally, patients have a worse prognosis if they have MSS. Aim and Objective: To Determine whether sarcopenia alone or in combination with malnutrition is a better predictor of clinical outcomes (extended length of hospital stay and hospital readmission) in hospitalized patients.Methods:It’s a Hospital-based Cross-sectional study Conducted in Tertiary Care Hospital over Hospitalized Patients during the period of January 2023 - March 2023, All the Hospitalized Patients with age at least 18 years old and Give consent were included and Participants who did not give consent to participate in the study were excluded. Critically ill patients who couldn’t respond were also excluded from the study, So total sample size was 150. Malnutrition were assessed by MNA-SF (Mini - Nutritional Assessment - Short Form) and GLIM (Global Leadership Initiative on Malnutrition) criteria. Sarcopenia was assessed by Muscle mass and muscle strength which were measured by Hand Dynamometer and BIA (Bio-impedance Analyser).Result:A total of 150 patients were included in the current analysis, the mean age of patients was 48+5 Years. 43%(n=65) were males. The Mean of actual body weight and BMI was 50 +8, and 23+5 Kg/m2, respectively. Around 80% (n=120) have low HSG and 59% (n=89) were found to be sarcopenic. Around 46% (n=69) were found to have Malnutrition. The MSS was Diagnosed in 57 patients (38%). Conclusion:The study provides evidence that malnutrition and sarcopenia are prevalent in hospitalized patients and are associated with worse outcomes, including prolonged length of stay and readmission. The findings highlight the importance of screening for malnutrition and sarcopenia in clinical practice and implementing appropriate interventions to optimize patient outcomes