Aim: To assess psychiatric comorbidities, self-esteem, coping skills, and quality of life in patients with Psoriasis affecting physical appearance in a tertiary care teaching hospital. Material and Methods: The present cross-sectional study was conducted among 29 Patients diagnosed to have psoriasis visiting Out-patient Dept. of Dermatology, Sri Siddhartha Medical College& Hospital. After obtaining the consent, semi-structured proforma, MINI, HAM-D and HAM-A was administered by the principal investigator. The scales RSES, PACS-R BREF-COPE, and BBQ scale were given to the participants to complete. Results: In psoriasis, 9 patients had no depressive symptoms, 12 patients showed mild depressive symptoms and 8 patients showed moderate depressive symptoms. In psoriasis patients, 2 patients had no anxiety symptoms, 24 patients had mild anxiety view and 3 patients showed moderate anxiety symptoms. Conclusion: Major depression disorder is the most frequent psychiatric disorder seen in patients with psoriasis. Mild to moderate anxiety levels are seen in patients with psoriasis. Low self-esteem is seen in patients with psoriasis. Even after having significant anxiety, depression and emotional instability patients psoriasis would cope well. Patients having psychiatric illness were suffering from low quality of life.