Abstract Issue

Volume 12 Issue 2 ( April- June) 2023

Original Articles

Clinico-aetiological profile and short-term outcome of children presenting with convulsive status epilepticus- Experience of a tertiary care center
Dr Md Razazaque, Dr Jyotsna Saran, Dr Akhilesh Kumar, Dr Alka Singh, Dr Girijanand Jha

Background and Objectives:Paediatric status epilepticus (SE) is a common major medical and neurological emergency of utmost importance due to the associated mortality and morbidity. It can present with variable clinical features and may have different aetiologies which vary with age and community. Despite some progress made over the last decade due to protocolised treatment, the mortality (10-20%) and morbidity (25-35%) related to paediatric SE remains high. This study was undertaken to study demography, clinical features, aetiology, response to treatment with AEDs and short-term outcome of children with SE.Methods:The present study was conducted at Paediatrics department of a tertiary care level teaching institute over two years from August 2020 to July 2022 on children >6 months to <15 years of age presenting to I.P.D or E.R of our deptartment with status epilepticus OR children admitted for other illnesses but developing status epilepticus during the course of their illness.Result: Over the study period, 82 children were enrolled in this study out of which 48 were males and 34 were females with male: female ratio of 1.4:1. Mean age of the study participants was 5.08 ± 2.46 years and mean weight of the children was 16.84 ± 4.58 kg. Majority of the children (n=49, 59.8%) were less than five years of age. Onset of SE occurred before hospitalization to our institute in the majority of children (n= 75, 91.5%). A total of 37 (45.1%) patients had received pre-hospital treatment with one or more AED. The most common etiological group for SE was found to be acute symptomatic group (57.3%) followed remote symptomatic group (23.1%). Overall, the seizure episode terminated after administration of BZD in 38 (46.3%) children and the rest required administration of second- and/or third-line drugs. Mean duration of midazolam infusion at which convulsions were controlled was 8.43± 5.76 hours and mean dose of midazolam infusion required for controlling convulsions was 4.49± 2.65 mcg/kg/min. Mean duration of PICU stay was 4.23 ± 3.14 days and mean duration of hospitalization was 6.4 ± 4.07 days. 12 children (14.6%) died during the hospital stay.Conclusion:Acute symptomatic aetiology (predominantly infectious causes) was the commonest cause of SE in our region. BZD is effective in controlling seizures in nearly half of such children. So, community physicians and the paramedics should be trained about early initiation of intravenous or nasal/buccal BZD in developing countries.Abbreviations: AED: antiepileptic drug; BZD: benzodiazepine; S.D: standard deviation; SE: status epilepticus; ESE: established status epilepticus; RSE: refractory status epilepticus

 
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