Background: A continual/chronic ulcer or wound doesn't heal in an orderly set of degrees and in a predictable quantity of time as most of wounds do; wounds that don't heal within 03 months are considered persistent.Aim: To establish the efficacy of collagen granules in healing these chronic wounds.Methods:In this prospective study, a total of 178 patients were divided into two groups, according to the type of dressing i.e., for group A patients collagen granules were used, and for group B patients normal saline dressings were used. The collagen granules used for this study were“Biofil”.Results:There has been a significant decrease in the size and depth of the ulcers treated with collagen granules as compared to the normal saline-soaked dressing.Conclusion:The usage of collagen granules dressing has elevated the rate of wound recuperation in chronic ulcers; in this study, the authors have observed that the rate of wound restoration was notably higher in using collagen granules for chronic wound management.These materials are promising new technology in the field of wound healing and arecost-effective.