Background: Typhoid fever occurs in all parts of the world but over the past four decades with the advent of improvements in food handling and water /sewage treatment, enteric fever has become a rare occurrence in the western part of the world. But in contrast it continues to be a major public health problem where there is substandard water supply, sanitation and poor hygiene mainly in low socio-economic strata and it is endemic in most developing countries including India where patients report throughout the year with monsoon clustering patterns. Low standards of living, rapid population growth, increased urbanization, inadequate human waste treatment, limited water supply and overburdened health care system are the main reasons behind the higher endemicity in India. Aim: Therefore, this study is aimed to study the antibiotic sensitivity pattern among typhoid fever cases in a tertiary care setting, which most often caters to referred cases unsuccessfully treated elsewhere. Methods: The present study was conducted at Dept. of PEDIATRICS, NALANDA MEDICAL COLLEGE AND HOSPITAL, PATNA, after obtaining clearance from institutional ethical committee, Informed consent was taken from the parents before including into the study. Results: In the present study, minimum age was 1year and maximum age was 15 years. Number of cases below 2 years constituted 12.66%, 2-10 years constituted 54% and 10-15 years constituted 33.33%. Overall cases of males were 58.67% and of female were 41.33%. In each age group male cases were more than female cases. Conclusions: In cephalosporin group, ceftriaxone sensitivity is high and it is in use since last two decades with good results.An adequate trial for antibiotics like chloramphenicol or oral co-trimoxazole can be tried before starting injectable antibiotics due to increased emergence of sensitivity to these drugs.