Background: Papillomaviruses (PVs) are a diverse group of DNA viruses known to cause epithelial lesions and cancers. This study aims to investigate the prevalence, characteristics, and potential implications of episomal papillomavirus infection in the human placenta. Materials & Methods: 84 placentae of pregnant women were selected. Genomic DNA was extracted from placental tissue using standard protocols. Papillomavirus infection was detected using a combination of polymerase chain reaction (PCR) amplification targeting conserved regions of the L1 gene and subsequent DNA sequencing for viral typing. Results: Out of 84 placenatae, HPV was identified in 65 (77.3%). In HPV positive (65) and HPV negative (19), gestational age was 36.4 weeks and 38.2, maternal age was 31.2 and 30.5 years, maternal BMI was 26.2 and 25.8, Fetal PGC was 36.5 and 33.2, pre- term birth was seen in 12 and 2, intrauterine fetal death was seen in 5 and 1, acute chorioamnionitis was seen in 5 and 2, gestational/Diabetes mellitus was seen in 6 and 2 and pre-eclampsia was seen in 4 and 0. The difference was significant (P< 0.05). Conclusion: There was high prevalence of HPV in placentae. HPV positive cases had higher prevalence of intrauterine fetal death and acute chorioamnionitis.