Aim and objective: To evaluate the anti-inflammatory effect of Atorvastatin in experimentally induced paw edema in adult male albino rats. Materials and methods: Eighteen inbred adult male albino rats weighing about 150-200 gms were selected from Central Animal House, Madurai medical college, Madurai. They were divided into three groups, each group containing six rats. The group I was considered as control group, received normal feed and water.Group II was considered as standard received Tab. Indomethacin 10mg/kg per orally. Group III was considered as test group, received Tab. Atorvastatin 6mg/kg per orally. Paw edema was produced by sub plantar injection of carrageenan. The drugs were administered one hour prior to carrageenan injection. The paw edema was measured by using plethysmography immediately before, after 1 hour, 2 hours and 3 hours of injecting carrageenan. The difference between the left and right paw edema volume was determined and the percentage reduction was calculated and compared to control animals after administrating standard and test drugs. The results were tabulated and analysed by suitable statistical method. Results: 6mg/kg Atorvastatin group and 10mg/kg Indomethacin group showed significant anti-inflammatory activity in compared to the control group. Conclusion: Atorvastatin has anti-inflammatory activity which is comparable to indomethacin.However studies in chronic models of inflammation are needed to confirm safety.