Background: Okra a valued vegetable for its economic and nutritional value is often affected by a number of fungal infections having detrimental effect on its production. Powdery mildew, Fusarium wilt, Cercospora leaf spot and Anthracnose are the most common fungal diseases which not only hinder a plant's capacity to grow and produce, but they also make the produce less marketable. This study is an attempt towards procuring a potent phytochemical agent against the common fungal agents affecting okra. Methods: In the present study, gene list was gathered from MBGD (Microbial Genome Database for Comparative Analysis) and imported into Cytoscape to create gene network analysis. The “dnaK” gene was identified as the priority gene for phytochemical design construction by Swiss Model. Furthermore, AdMETLab 3.0 was used to screen antifungal phytochemicals based on Lipinski's rule of five. Results: Molecular docking done between the phytochemicals and the selected priority gene, revealed the phytochemicals which showed various degree of antifungal activity. Consequently, the results suggest which phytochemicals have antifungal properties that work best and which ones should be combined to create organic fungicides. Among these, the most potent molecule was found to be berberine. Conclusion: This is the first study to the best of our knowledge which attempts to decode the antifungal action of berberine on fungal infections of okra. It seeks to promote the sustainable production of ladyfinger and lower the demand for artificial pesticides.