Introduction: The prevalence of personality disorders (PDs) is significantly greater in the pain population than in the general population or in medical or psychiatric populations.. The present study was conducted to find out the effect of personality type on response to physical therapy treatment methods in chronic low back pain. Materials and Methods: The present study was a prospective cohort study among 50 patients of chronic low backache. The details regarding the following for measuring pain and disability i.e., the Oswestry Disability Index (ODI), Numeric Pain Rating Scale (NPRS), and the Pain Catastrophizing Scale (PCS), and Eysenck Personality Questionnaire (EPI) questionnaire. Two-tailed p-values of less than 0.05 were considered statistically significant. Results: Correlational analysis, revealed statistically significant relationships between the EPI-N score and the pain outcome measures that includes pain catastrophizing scale score (p < 0.001, r= 0.392), oswestry disability index score (p = <0.05ρ = -0.102), that reports significant positive association of neuroticism with pain catastrophizing scale and oswestry disability index. Conclusion: The present study concludes that personality traits are associated with treatment in chronic low back pain patients. Clinicians should recognize the influence of these specific personality traits to provide a more positive approach to the clinical problem.