Aim: To analyse proliferative indices (Ki-67 & Agnors) with grades of breast carcinoma. Material and Methods: The present observational cross-sectional study was conducted among 42 Breast biopsies reported histopathologically as Breast carcinoma. Demographic details of the patient were documented. Presenting complaints of the patient along with detailed history was recorded. Relevant cytological and radiological findings were documented. We prepared two sections, first one was stained with special stain i.e. AgNOR and second with immunohistochemical marker i.e. Ki-67. Histopathological grading of all breast malignant biopsies were done according to Notthingham grading system. Expression of AgNORs and Ki-67 was documented and analysed using SPSS version 24. Results: Notthingham Grade I was revealed maximum in subjects with Ki67 <1%, grade II in subjects with Ki67 1-10% while grade III was found maximum in subjects with Ki67 >10%. Hence higher Notthingham Grade was related more with higher Ki67 score. Mean AgNOR score was found maximum in Notthingham Grade III while least in Notthingham Grade I, though no statistically significant difference was found as p>0.05. Conclusion: This research demonstrated that Ki-67 index can be used to classify tumours into distinct prognostically meaningful clinical outcomes.