Purpose: Carpal tunnel syndrome (CTS) is the most common nerve entrapment syndrome. CTS account for approximately 90% of all entrapment neuropathies. The majority of cases are due to compression or irritation of the median nerve in the carpal canal. With advancement in biomechanical and biological research on idiopathic carpal tunnel syndrome, the insight on the pathophysiology of carpal tunnel syndrome has gained much clinical relevance. Open carpal tunnel release is still a gold standard procedure for carpal tunnel syndrome, which has evolved into mini-open procedure with development of new devices. This paper describes comprehensive and retrospective experience of a single center in 48 patients. Methods: A retrospective study was performed at Hamdard Institute of Medical Sciences and Research New Delhi India, and in this retrospective study, we included 48 patients (66 wrists) who received open carpal tunnel release between April 2017 and April 2022. A total of 46 patients (64 wrists) were followed up. Results: A total of 46 patients (64 wrists) were followed up for an average of 12months. 2 patients were lost during follow up. The follow up outcomes for median scores on QDASH scales. The above scale scores at 1 month postoperatively, 3 months postoperatively, and the last follow-up were significantly lower than those preoperatively, and the differences were statistically significant (P < 0.001). Similarly, the scale scores at 3 months postoperatively and the last follow-up also changed compared with scores at 1 month postoperatively; the differences were statistically significant (P < 0.001). Conclusions: It was concluded that open carpal tunnel release remains a safe and reliable treatment for carpal tunnel syndrome. The very low incidence of serious complications from the open technique of CTR, when compared with endoscopic CTR as published by different authors in the literature, and the comparable clinical results, appears to make the open technique a safer and preferable option.