Education about menstrual cycle since childhood could result in decreased suffering of majority of females. Therefore, the present study was undertaken to assess the attitude of adolescent girls towards menstrual cycle. Material and Methods: The present question naire based cross-sectional study was conducted among 700 adolescent girls (350 in each group) aged between10-17 years in rural and urban schools respectively studying at government as well as private schools of urban and rural are a respectively. The questionnaire questions were asked in 5 points likert scale (1 being strongly disagree; 2 as disagree; 3as neutral; 4 as agree and 5 as strongly agree).Results: We found that majority of the girls from rural setting were not ready when they got their firstperiods. However, participants from the both the settings were not aware how to respond to their first period. Knowledge regarding the physical changes taking placed uring menstruation were more among the urban area as compared to rural setting. Girls living in rural areas were more comfortable with their friends followed by their sisters in talking about menstrual problems. Conclusion: Adolescents must be recognized as a priority target group. There were substantial lacunae inthe knowledge about reproductive health. There are different types of misconception, myths, restriction and lack of menstruation related knowledge. There is need for special policies andprograms to address the problems of adolescents to prevent diseases and promote good healthin them.