Aim: To study the association between mental incompatibility among married couples and depressive disorders. Materials and Methods: Married couples visiting the Psychiatry OPD at Teerthankar Mahaveer Medical College & Research Centre (TMMC & RC) with one of the partners diagnosed with depressive disorders as per ICD-10 criteria by our study team. After taking written informed consent, Patient Health Questionnaire-9 was applied only to the normal spouse, Beck Depression Inventory Second Editionwas applied only to the spouse diagnosed of depression and Dyadic Adjustment Scale was applied to both the patient and the spouse to assess approximate extent of agreement or disagreement between both.Results: The majority of the subjects i.e. the patients in the present study were females (67.3%) with mean age being 37.50 years (SD: 9.32). All of the participants were married and majority of them belonged to Muslim religion (63.4%). Pearson correlation analysis revealed inverse significant correlation (r=-0.46, p<0.01) between score of PHQ spouse and DAS spouse i.e. with increase in score of PHQ spouse, there was decrease in score of DAS spouse. Similar relationship was observed for BDI II and DAS Score of patient (p=0.041). Conclusion: Patients with depression showed more distress and low adjustment with their spouses.Similarly spouses with partners suffering from depression showed poor marital adjustment as analyzed by Dyadic Adjustment Scale. Thus mental incompatibility in the married life was associated with the depressive disorders.