Background: Conjunctivitis is characterized by symptoms such as irritation, itching, a sensation of a foreign body in the eye, and excessive tearing or discharge. The primary pharmacotherapy options for the treatment of bacterial conjunctivitis are topical aminoglycosides, fluoroquinolones, and macrolides. Mostly empirical topical antibiotics are used to treat bacterial conjunctivitis without preliminary bacteriological identification. So first-line antibiotics should be more effective, cure at a higher rate, and have a favorable safety profile. Hence; the present study was conducted for comparative efficacy evaluation of moxifloxacin 0.5% eye drops vs tobramycin 0.3% eye drops vs azithromycin 1.5% eye drops for purulent bacterial conjunctivitis in children at a tertiary care hospital.Materials & Methods: A total of 60 children within the age range of 3 years to 15 years were enrolled. All the patients were randomized into three study groups as follows: Group 1- Patients receiving Moxifloxacin 0.5% Eye Drops, Group 2- Patients receiving Tobramycin 0.3% and Group 3- Patients receiving Azithromycin 1.5 %. All patients receive eyedrops according to their specific group, four times a day for moxifloxacin and tobramycin, and twice a day for azithromycin. The cardinal clinical indicators of bacterial conjunctivitis were evaluated for each eye using a slit lamp, and a grading system was applied. The main efficacy measure was defined as clinical resolution, characterized by the absence of bulbar conjunctival injection and purulent discharge in the most affected eye by the seventh day.Results: Mean age of the patients of group 1, group 2 and group 3 was 5.9 years, 4.9 years and 5.2 years respectively. 65 percent, 60 percent and 50 percent of the subjects of group 1, group 2 and group 3 were boys. Conjunctival purulent discharge was severe in majority of cases of all the three study groups at baseline. Clinical cure rate after 7 days was 85.5 percent, 60 percent and 85.5 percent among patients of group 1, group 2 and group 3 respectively. Hence;clinical cure rate was similar for group 1 and group 3 and was significantly lower for subjects of group 2.Conclusion: While managing Pediatric Population with Purulent Bacterial Conjunctivitis, the efficacy of moxifloxacin and Azithromycin was similar and was significantly better in comparison to Tobramycin.