Background: Chronic and non-healing wounds present a significant challenge in clinical practice. Negative Pressure Wound Therapy (NPWT) has gained recognition as an advanced method for promoting wound healing, especially in complex wounds. This study compares the efficacy of NPWT with conventional moist dressings in wound healing by delayed primary intention and secondary intention.Methods: A comparative interventional study was conducted on 60 patients with chronic non-healing wounds. Patients were randomly assigned to two groups: NPWT (Group A) and conventional dressing (Group B). Group A received NPWT with dressings changed every 72 hours, while Group B underwent conventional moist (normal saline) dressing changes every 24 hours. Wound healing was assessed using parameters such as time to wound closure, percentage of wound area healed, wound dimension reduction, and the number of dressings required.Results: The study revealed a statistically significant difference in the time taken for wound closure between the two groups. Patients in the NPWT group experienced faster wound healing, with a mean wound closure time significantly lower than that of the conventional dressing group (p < 0.05). Additionally, NPWT resulted in a greater percentage of wound area healed and fewer dressing changes compared to conventional methods. Diabetic foot ulcers were the most common wound type in both groups.Conclusion: NPWT demonstrated superior efficacy in promoting wound healing compared to conventional saline dressings. The therapy not only expedited wound closure but also reduced the need for frequent dressing changes, making it a cost-effective and efficient option for chronic wound management. Given its effectiveness, NPWT should be considered a viable treatment modality, particularly in cases of difficult-to-heal wounds.