Background: This study aims to identify various congenital and acquired disorders causing permanent disability in patients attending the disability clinic of the Department of Ophthalmology at Jorhat Medical College and Hospital, Assam, over a period of six months from March 2023 to August 2023. Methods: A hospital-based cross-sectional study. All the patients fulfilling the inclusion criteria were enrolled in the study for a period of 6 months from March 2023 to August 2023 and assessed for age and sex at presentation, type of visual anomalies, etiology and clinical presentation. Results: A total of 50 cases were assessed, out of which 28 were males and 32 were females(M:F=0.88:1).The most common age group at presentation was 6-10 years (38 %). The causes included both congenital as well as acquired conditions. The most frequent ocular anomaly noted was Pathological/Degenerative Myopia. Conclusions: In a developing country like India, a significant portion of childhood and adult blindness is preventable. Action is needed to prevent blindness from vitamin A deficiency, measles, refractive error, amblyopia, retinopathy of prematurity, external ocular infections and chemical injuries. Specialist paediatric and optical services are required to manage cataract and glaucoma. Furtherworkis indicated to elucidate the causes of anophthalmos, microphthalmos and coloboma. It would be useful to document thechanging patterns in the causes of ocular disability to allow early action against emerging avoidable causes.