Aim: To evaluate the impact of lung volume reduction surgery (LVRS) on quality of life, physical function, and lung function in patients with advanced chronic obstructive pulmonary disease (COPD). Materials and Methods: This prospective cohort study enrolled 110 patients with advanced COPD (FEV1 < 45% predicted), significant hyperinflation, and frequent exacerbations despite optimal medical therapy. Exclusion criteria included significant comorbid conditions or previous pulmonary interventions. Participants underwent LVRS, conducted by a specialized thoracic surgery team. Quality of life was assessed using the St. George’s Respiratory Questionnaire (SGRQ), physical function with the 6-Minute Walk Test (6MWT), and lung function with spirometry and body plethysmography. Assessments were conducted preoperatively and at three and six months post-surgery. Results: Baseline SGRQ scores averaged 69.34, improving to 56.81 at three months and 54.34 at six months post-LVRS (p<0.01), indicating significant quality-of-life improvement. Physical function, as measured by 6MWT, increased from a baseline distance of 320.45 meters to 382.56 meters at six months (p<0.01). Pulmonary function tests showed significant enhancements, with FEV1 rising from 39.12% predicted at baseline to 48.12% at six months (p<0.01). Complications were manageable, with 7.27% experiencing pneumonia, 10.91% prolonged air leaks, and 16.36% requiring supplemental oxygen. Conclusion: LVRS significantly improves quality of life, exercise capacity, and lung function in carefully selected patients with advanced COPD. While complications exist, appropriate patient selection and postoperative management can maximize therapeutic benefits, making LVRS an effective intervention for enhancing outcomes in severe COPD.