Background: Chronic kidney disease (CKD) is one of the most important chronic, non-communicable diseases. CKD is a global health burden due to loss of renal function progressively and is a pathophysiological process with multiple etiologies which includes diabetes and hypertension. Carcinoembryonic antigen (CEA) is excreted by certain embryonic and adult tissues in addition to adenocarcinoma of the digestive organs, but its level is also high in chronic renal disorder. Our study was aimed to assess and compare the status of serum CEA level in chronic kidney disease subjects and healthy controls. Materials and Methods: Thecase-control study was conducted on 220 CKD patients.Cases (n = 220) were selected from the Medical OPD and ward of Jawahar Lal Nehru Medical College and Associated Group of Hospitals, Ajmer. Age and sex-matched healthy controls (n = 100) were selected from MOPD. The present study was approved by Institutional Ethical Committee. All samples were collected under aseptic conditions from the antecubital vein for estimation of biochemical parameters. Results: The mean activity of Serum CEA was significantly higher in CKD subjects as compared to healthy controls (p < 0.0001).Positive pearson correlation of serum creatinine with serum CEA was found (r= 0.73).Conclusion: Serum CEA can be used as a biomarker for the early detection of CKD in the general population to prevent the morbidity and mortality which are associated with CKD. If CKD is detected early and managed appropriately the deterioration in kidney functions can be slowed and the risk of cardiovascular diseases in renal patients can be reduced.