Aim: To explore the anatomical variability of the sciatic nerve and discuss its implications for clinical practice. Materials and methods: A study was undertaken to assess the course and branching of the sciatic nerve (SN) by examining around 25 cadavers, totaling 50 lower limbs. The dissections concentrated on the gluteal region, the posterior thigh, and the popliteal fossa. The topographical delineation aimed to enhance the understanding of the anatomical context surrounding SN division. Data analysis was done using basic quantitative indicators of frequency and proportions. Results: In this study, which involved 25 cadavers and a total of 50 gluteal regions, the course and division of the sciatic nerve (SN) were investigated. The examination of 50 specimens or limbs revealed variations in the division of the sciatic nerve, with 66% showing a normal division at the superior angle of the popliteal fossa, 20% displaying a high division within the pelvis, and 14% demonstrating a high division in the back of the thigh. Conclusion: Comprehending the variations in the course and branching of the sciatic nerve (SN) is vital for surgeons performing procedures in the gluteal region. These anatomical differences can lead to conditions like piriformis syndrome and may affect the efficacy of nerve blocks.