Original Articles
Breast Cancer Subtypes, Tumor Size, and Lymph Node Metastasis: A Retrospective Analysis of 442 Patients | |
Dr. Akanksh B Shetty, Dr. Abhijna Prasad | |
Breast cancer is a heterogeneous disease with various subtypes that exhibit distinct biological behaviors and prognostic outcomes. Despite the robustness of this relationship in many breast cancer cases, emerging research reveals significant variations in the correlation between tumor size and lymph node metastasis across specific subgroups. In this retrospective study, we analyzed the clinical and pathological features of 442 breast cancer patients diagnosed between year 2017 and 2023 at A.J. Institute of Medical Sciences and Research Centre,Mangalore, Karnataka, India. Luminal A patients generally presented with lower-grade and early-stage tumors, while TNBC and HER2-positive subtype were associated with higher-grade tumors and more aggressive clinical features. The number of metastatic lymph nodes and histologic grade emerged as strong predictors of survival across all subtypings, with TNBC showing the highest risk for poor outcomes. These findings underscore the importance of considering both tumor biology and clinical variables in predicting patient outcomes and guiding treatment strategies. |
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