Background:Rapid growth, high local aggressiveness, and early metastasis to the lungs and other distant bones are characteristics of osteosarcoma, a highly malignant bone tumor. The present study was conducted to assess prognostic factors in osteosarcoma. Materials &Methods:47 cases of osteosarcoma of both genders were selected. Parameters such as clinical characteristics (location of tumour, largest dimension of tumour, staging, maximal alkaline phosphatase [ALP] level, calcium and phosphate levels before the start of treatment, and presence of pathological fracture), treatment-related characteristics etc. were recorded. Results:Out of 47 patients, 27 were males and 20 were females. The mean time from symptom onset to presentation was 8.1 months, follow-up interval was 54.3 months, alkaline phosphatase before diagnosis was 214.5 IU/L, serum calcium before diagnosis was 2.6 mmol/L, pathological fracture was seen in 5, time from diagnosis to start of chemotherapy was 9.2 days. The prognostic factors identified for OS included local aggressiveness, the presence of metastasis at diagnosis and throughout, and a larger tumour dimension contributed to OS. The difference was significant (P< 0.05). Conclusion: There are significant correlations between age at the time of diagnosis, tumor size, tumor location, and surgery and overall survival of patients with osteosarcoma. Male gender, larger tumor sizewere potentially responsible for poor prognosis in patients with osteosarcoma.