Background: The present study was conducted for comparing the efficacy of Escitalopram and paroxetine in the treatment of generalized anxiety disorder. Materials & methods: A cohort of 100 patients diagnosed with generalized anxiety disorder was recruited for the study. Comprehensive demographic and clinical information were collected for each participant. The patients were randomly assigned to one of two treatment groups, with 50 individuals in each: the Escitalopram group and the Paroxetine group. The efficacy and tolerability of the treatments were evaluated at baseline, as well as at 6- and 12-weeks post-treatment. All data were documented in a Microsoft Excel spreadsheet for comparison. Statistical analyses were conducted using SPSS software. Results: Mean age of the patients of the Escitalopram groupand Paroxetine group was 41.7 years and 43.9 years respectively. Majority proportion of patients were males. Significant improvement was seen in both the study groups. However; improvement was better in Escitalopram group in comparison to Paroxetine group. Conclusion: Escitalopram was more efficacious in generalized anxiety disorder in comparison to paroxetine.