Background: Androgenic Alopecia (AGA) is a common condition causing significant hair loss in both men and women globally. It is driven by genetic factors and the hormone dihydrotestosterone (DHT), which leads to hair follicle miniaturization. Traditional treatments, such as oral Finasteride and topical Minoxidil, have shown varying effectiveness, prompting the exploration of alternative therapies. Platelet-Rich Plasma (PRP) therapy has emerged as a potential treatment, utilizing autologous growth factors to stimulate hair growth. This study aims to compare the efficacy of topical Minoxidil (5%) and PRP injections in treating AGAfocusing on hair density improvement, reduction in hair lossand overall patient satisfaction. Methodology: This observational comparative study was conducted at the Department of Dermatology, Venereology, and Leprosy at the National Institute of Medical Sciences Research and Hospital in Jaipur, India. A total of 80 patients diagnosed with AGA were recruited and randomly divided into two groups. Group A received topical Minoxidil (5%) solution applied twice daily, while Group B received PRP injections administered intradermally at four-week intervals over a period of four months. Baseline and follow-up assessments, including hair density measurements and patient satisfaction surveys, were conducted every four weeks. The efficacy of the treatments was evaluated using standardized clinical and photographic assessments. Results: The results of the study indicated that both topical Minoxidil and PRP injections were effective in reducing hair loss and improving hair density in patients with AGA. Significant improvements were observed in both groups, with patients reporting increased hair growth and satisfaction with the treatments. PRP therapy demonstrated slightly higher efficacy in certain parameters, such as hair density and patient satisfaction scores. However, both treatments were well-tolerated, with minimal side effects reported. The study's findings suggest that PRP therapy could serve as a valuable alternative for patients who do not respond adequately to traditional treatments like Minoxidil. Conclusion: This study highlights the comparative efficacy of topical Minoxidil and PRP therapy for treating androgenic alopecia. Both treatments were effective, with PRP therapy demonstrating marginally better results. Given its minimally invasive nature and positive patient outcomes, PRP therapy presents a promising alternative or adjunct to traditional AGA treatments, supporting its integration into clinical practice.