Background: A TSB >5 mg/dL is known as neonatal hyperbilirubinemia, and it is a common clinical disease in infants. The present study was conducted to evaluate the predictive value of serum bilirubin within 6 hours of life for subsequent hyperbilirubinaemia in healthy term neonates. Materials & Methods: 80 term neonates of both genders were selected. Total serum bilirubin, direct and indirect bilirubin was estimated first, within 6 hours of life and second, after 72 hours of life by Modified Van den Bergh’s kit method. Results: Out of 80 patients, 48 were males and 32 were females. Parity 1 was present in 42, and >2 in 38. Mode of delivery was vaginal seen in 59 and caesarean in 21. Blood group A was present in 4, B in 14, AB in 28 and O in 34. The difference was significant (P< 0.05). The mean TSB level between 2.6- 4.0 mg/dl was seen in 25, 4.1- 5.5 mg/dl in 43 and >5.6 mg/dl in 12 patients. The difference was significant (P< 0.05).TSB level (mg/dl) between 7.7-10.2 was seen in 4, 10.3-12.7 in 21, 12.8-15.3 in 40 and >15.4 in 15 patients. The difference was significant (P< 0.05). Hyperbilirubinemia was seen in 2 with bilirubin level between 2.6-4, in 5 with bilirubin level between 4.1-5.5 and in 8 with bilirubin level >5.6. The difference was significant (P< 0.05). Conclusion: If the total blood bilirubin level is greater than 5 mg/dL within 6 hours of delivery, it may be a predictor of the likelihood of developing hyperbilirubinemia later on.