Objectives: This study aims to evaluate the effectiveness of conventional ultrasound (US) therapy in the treatment of upper trapezius trigger point. Patients and Methods: Fifty-four patients (23 males, 31 females; mean age 29.8±5.2 years; range, 22 to 46 years) with upper trapezius trigger point were included in this prospective, randomized, placebo-controlled study. Patients were randomized into two groups by computerized method as US group (n=27) and placebo group (n=27). Ten sessions of US were applied to the US group and 10 sessions of placebo US were applied to the placebo group. Treatment effectiveness was evaluated with Visual Analog Scale (VAS). Results: Pain values after treatment in both groups decreased significantly (p<0.05) compared to before treatment. In the US group, the decrease in VAS before and after treatment was significantly higher (p<0.05) than in the placebo group. Conclusion: Our findings show that conventional US therapy is effective in the treatment of upper trapezius trigger point.