Background and aim: The second peak of the second wave of covid-19 in India was least studied. Objective of the study was to assess the mortality, morbidity and its associations in the second peak of second wave of covid-19. Materials and methods: This was a cross sectional study conducted at a tertiary care centre in Kerala.Covid patients’ demographic details, symptomatology, signs, comorbidities, previous history of covid and duration of hospital stay were recorded.Patients were grouped into those with hypoxia requiring oxygen (O2) supplementation and those requiring high flow oxygen or ventilatory supports.Patients with oxygen saturation (SpO2) less than 92 are considered hypoxic. Patients were also grouped into those who received steroids, remdesvir and anticoagulants. Results: There were total of 190 patients. The mean age was 61.21 years ± 17.9 standard deviation (SD). Hypertension was the major comorbidityin 91(47.89%) patients.Twelvepatients (6.3%) expired. Sixty-one(32.1%) patients suffered hypoxia requiring oxygen supplementation and 21 patients(11%) required high flow oxygen or ventilatory supports. Age, hypertension and cardiovascular diseases showed significant association to hypoxia.Mortalitywas less in hypoxic patients on Remdesvir though the association was not significant. Conclusions: The second peak of second wave of covid suffered less mortality and morbidity when compared with the first wave and initial peak of second wave.Elderly patients were most hospitalised with significant association to hypoxia.Hypertension was the most common comorbidity and showed significant association to hypoxia.Thoughmortality was less in Remdesvir group, significant association could not be demonstrated.