Background: Sinusitis is one of the leading health care problems nowadays, increasing in both incidence and prevalence. Present study was aimed to study computed tomographical evaluation of anatomical variants of paranasal sinuses & related complications, to evaluate the detailed anatomy (normal anatomy, anatomical variation and the extent of the disease process) that are commonly encountered in the osteomeatal complex and lateral nasal wall. Material and Methods: Present study was single-center, prospective, observational study, conducted in patients with symptoms suggestive of acute/ chronic sinusitis and Complications related to anatomical variants of para nasal sinuses, underwent endoscopic nasal evaluation. Followed by CT scan paranasal sinus.Results: The demographic profile shows the most common age group to be between 21-25yrs. Among the 100 cases studied 63% (63) of patients are male and 37%(37) of patients are female.In our study most of the patients had more than one anatomical variation. Out of 100 patients studied, 88% (88) of patients had more than one anatomical variation, of these 62.5% (55) were males and 37.5% (33) were females. Only minor group of patients presented with one anatomical variation 12% (12). In our study all the patients had at least one anatomical variation. Anatomical variations may present unilaterally or bilaterally. In our study, 82 (82%) patients out of 100 patients had bilateral anatomical variation. Only 18 (18%) patients had unilateral disease. Conclusion: Our present prospective study of anatomical variation of osteomeatal complex reveals that, among the anatomical variations of the osteomeatal complex in patients with chronic sinusitis not responding to medical therapy, a combination of anatomical variations is more commonly found.