Background: Antibiotics have been widely employed for both the prevention and management of infections since the introduction of penicillin in the 1920s. This groundbreaking discovery, along with subsequent advancements, has profoundly altered medical practices and contributed to a substantial reduction in infection-related mortality rates. Consequently, the current study was undertaken to examine the prescribing patterns of antibiotics in postoperative patients who were admitted for gynaecological and orthopaedic surgeries. Material and methods: The current investigation involved a comprehensive review of the medical records of all patients aged 18 and older who were admitted to the gynaecology (n=50) and orthopaedic (n=50) departments. The data gathered included patient demographics such as age, reasons for surgical procedures, and details regarding the antibiotics prescribed, which encompassed dosage, duration, and method of administration. To ascertain the average number of antibiotics prescribed, the total count of antibiotics administered was divided by the number of case records examined. Furthermore, the study classified the antibiotics into categories of single-agent therapies, multidrug regimens, and fixed drug combinations, with results presented in both numerical and percentage formats. Results: A total of 50 patients were enrolled from the gynaecology ward and an additional 50 from the orthopaedic ward. The average age of patients in the gynaecology ward was 35.2 years, while those in the orthopaedic ward had a mean age of 42.8 years. In the gynaecology ward, the most frequently prescribed antibiotics included Ceftriaxone, Amoxicillin, and Amoxicillin combined with clavulanic acid. Conversely, in the orthopaedic ward, the predominant antibiotics prescribed were Amoxicillin with clavulanic acid, Amoxicillin, Cefuroxime, and Ceftriaxone. Conclusion: Understanding antibiotic prescribing patterns is essential for the development and implementation of localized antibiotic prescribing guidelines, which can effectively combat antibiotic resistance.