Introduction: Peptic ulcer disease (PUD) remains a significant global health concern, affecting millions of individuals annually. Objective: The main objective of the study is to find the role of pulp score to predict mortality and morbidity following peptic ulcer. Material and methods: This prospective cohort study was conducted and data were collected from 75 patients diagnosed with peptic ulcer. Data were collected from medical records to ensure comprehensive and accurate information. Upon admission, each patient’s demographic data, including age, gender, and the presence of comorbid conditions, were documented. Results: The study included 75 patients with peptic ulcer disease complications.Mean age of the patients was 56.73±5.68 years. The gender distribution included 60% males (n=45) and 40% females (n=30). A significant portion of the participants, 73.3% (n=55), had comorbid conditions, with hypertension (40%, n=30), diabetes mellitus (30%, n=23), and chronic kidney disease (20%, n=15) being the most common. Patients who received intervention within 6 hours (26.7%, n=20) had a mortality rate of 5% and a morbidity rate of 15%. Those treated between 6-12 hours (33.3%, n=25) experienced a mortality rate of 12% and morbidity rate of 24%. Conclusion: It is concluded that the PULP score is a highly effective tool for predicting mortality and morbidity in patients with peptic ulcer disease complications. Its superior predictive accuracy compared to other scoring systems supports its integration into clinical practice.