Background: It has been observed that changes in middle ear pressure during anesthesia can range from +400 mm H2O (392 daPa) when nitrous oxide is administered to as low as +500 mm H20 (+490 daPa) once it is stopped. The present study was conducted to compare the effects of sevoflurane versus isoflurane on middle ear pressure. Materials & Methods: 68 children age ranged 8-14 years of both genders were selected. On the day before surgery, ENT exams were performed, and patients were split into two groups of 34. Sevoflurane was given to group II, while isoflurane was given to group I. In order to verify the routine immitance screening of patients' ME, tympanometric functions were assessed using a middle ear analyzer. Results: Group I had 18 males and 16 females and group II had 17 males and 17 females. The mean height was 125.8 cm in group I and 121.6 cm in group II, weight in group I patients was 35.4 kgs and group II patients was 31.8 kgs, time of surgery was 35.2 minutes in group I and 28.6 minutes in group II, and time of anesthesia was 56.4 minutes in group I and 51.2 minutes in group II. The difference was significant (P< 0.05). The mean middle ear pressure at T0 was -18, at T1 was 28, at T2 was 76 and at T3 was 107 in group I. It was -19, 31, 84 and 138 at T0, T1, T2 and T3 respectively in right ear. It was -16, 35, 84 and 117 in group I and -14, 41, 78 and 140 at T0, T1, T2 and T3 respectively in left ear. The difference non- significant (P> 0.05). Conclusion: Since the rise in middle ear pressure under isoflurane anesthesia was less than that of sevoflurane, it can be used safely for ENT procedures.