Background: Mechanical ventilation, a lifesaving technique in critical care unit is under continual evolution in modern era. The care of children with invasive ventilation in poor nations with limited resources is tough. The purpose of the study is to find out complications & outcome of critically ill ventilated young infants up to 2 months age treated in Intensive Care Unit in a tertiary care hospital in India. Material & Methods: This observational study was conducted in the Department of Intensive Care Unit of SGRR Institute of Medical Sciences, Dehradun from January 2020 to December 2020. About 50 newborn infants up to 2 months age who required ventilation on various indications according to ICU protocol were the subject of this study. All newborns were monitored for problems which was found by daily clinical & radiological assessment. Patient was followed up to death or extubation. Moreover, they were extubated when clinically stable both haemodynamically & neurologically. Results: Out of 50 seriously ill patients, mortality rate was 74%. Mean age was 14±10.1 days, 84% patients were >34 weeks of gestational age and weight >2500 gm was 52%. Twenty (40%) patients suffered complication during ventilation & these were ET tube obstructed 35%, re-intubation 20%and VAP 15%, pneumothorax 15%, unintentional extubation 15% accordingly. Regarding outcome, in 34% patients, the duration of ventilation was more than 5 days, 62% patients stayed in ICU more than 7 days. However, approximately three fourth (74%) patients were dead and just 26% were survived within the study time. Conclusion: The prevalence of mortality in the ICU was high. Prolong ventilation (>5days) was key risk factor. Ventilator related problems developed in 40% individuals.