Pregnancy is associated with various forms of thrombotic microangiopathy, including hemolytic uremic syndrome (HUS). Pregnancy outcomes in patients with HUS are not well-documented. In this article, we go over the traits and prognoses of HUS-affected women who got pregnant while receiving perinatal care at the hospital. This was a retrospective single-center study conducted in India in 57 pregnant women. Different pregnancy outcomes and characteristics of HUS were recorded during different trimesters of pregnancy and also during the postpartum follow-up. The average age at the time of pregnancy-related HUS was 28±4.5 years. The risk for HUS occurrence was higher for the first pregnancy and it was lowered in subsequent pregnancies. HUS was diagnosed mainly in the third trimester. While in HUS presenting patients acute kindly injury was significant and thrombocytopenia was mild. There was no maternal death but neonatal or fetal deaths took place in 5 (8.8%) cases. Overall, 45 of 57 (79%) pregnancies resulted in a live birth and 5 (8.7%) pregnancies resulted in miscarriage. Progression of HUS to ESRD and CKD was progressive and occurred within 3 months. While streroid therapy brings kidney functions to the normal, relapse occurs in 65% patients and that lead to ESRD. Compared to patients with HUS in the postpartum period, patients presenting with HUS during pregnancy had a more frequent personal history of CKD or HUS. In conclusion, atypical HUS associated with pregnancy is a very serious condition that, if untreated, has a poor prognosis for the health of the mother's kidneys. In patients who are at risk for the disease, pregnancy appears to be a significant trigger.