Aim: The aim of this study was to analyze the patterns of injuries in road traffic accidents (RTAs) through autopsy-based examinations, focusing on the demographics of victims, types of injuries sustained, and the circumstances surrounding the accidents. Material and Methods: This cross-sectional, descriptive study was conducted at the mortuary of the District Hospital, Barabanki, over a one-year period from September 2017 to August 2018. The study included 100 victims of RTAs whose deaths occurred within the Barabanki district. Data was collected from post-mortem examinations, inquest reports, and hospital records. The patterns of injuries were evaluated, and statistical analysis was performed using the Chi-square test with SPSS version 21.0, considering a p-value of less than 0.05 as statistically significant. Results: The majority of RTA victims were males (77%) aged between 21-30 years (27%). Thoraco-abdominal injuries were the most common, observed in 66% of the cases, while 63% of the victims had head injuries, with intracranial hemorrhages present in 56% of cases. Alcohol intoxication played a significant role, particularly in the 31-40 year age group (68.8%). Shock and hemorrhage (56%) and coma due to head injury (44%) were the leading causes of death. Conclusion: The findings highlight the high mortality and severe injuries sustained in RTAs, particularly in middle-aged males. Alcohol use and head injuries are key contributors to fatalities, underscoring the need for enhanced road safety measures and timely medical intervention.