Background: Lower gastrointestinal bleeding (LGIB) is characterized as any hemorrhage occurring distal to the ligament of Treitz. This condition accounts for approximately 20% of all gastrointestinal bleeding (GIB) cases, The present study was conducted to evaluate clinical profile of chronic lower gastrointestinal bleeding. Materials &Methods: A cohort of 50 patients aged between 30 and 70 years was assessed. Comprehensive demographic and clinical information were collected for each participant. Following a thorough physical examination and routine laboratory investigations, all patients underwent fibro-optic colonoscopy. This colonoscopic evaluation was conducted subsequent to appropriate bowel preparation. The bowel was cleansed using polyethylene glycol administered four hours prior to the procedure. Most patients exhibited effective bowel cleansing. Those who experienced insufficient bowel preparation during the initial examination were subjected to a repeat preparation using the same protocol. Histopathological analysis was conducted as needed for diagnostic clarification. All the results were recorded in Microsoft excel sheet and was subjected to statistical analysis using SPSS software. Results: A total of 100 patients were assessed in this study. The average age of the participants was 41.6 years, with 62% identified as male. Additionally, 65% of the patients resided in urban areas. Painless bleeding, Painful bleeding, Stool with occult blood positive, Stool mixed with blood, Anemia, Blood transfusion needed and Pain abdomen was seen in 79 percent, 39 percent, 5 percent, 2 percent, 46 percent, 9 percent and 31 percent of the patients respectively. Hemorrhoids, Ulcerative colitis/ crohn’s disease, Carcinoma colon, Infective etiology and Non-specific colitis was found to be present as etiologic profile in 25 percent, 22 percent, 21 percent, 17 percent and 15 percent of the patients respectively. Conclusion: LGIB is a relatively frequent clinical manifestation observed in numerous patients experiencing intestinal hemorrhage, primarily affecting a younger demographic. The clinical range of LGIB is diverse, and colonoscopy is regarded as the preferred initial diagnostic procedure, offering a substantial diagnostic yield.