Background: PPH may occur due to failure of uterine contraction after delivery and subsequently leading to loss of 500 ml or more blood during vaginal delivery and 1000 ml or more during caesarean delivery. Misoprostol is prostaglandin can be given by oral, vaginal, sub lingual and rectal route. Its dose may vary from 200 μg to 1000 μg. Aim: To compare the efficacy and side effects of 2 sublingual dose of Misoprostol for prevention of PPH. Methodology: The present observational study was conducted to compare the effectiveness of sublingual misoprostol 2 dose for prevention of post-partum haemorrhage in patient with caesarean delivery. A total 200 subjects were divided into 2 groups namely M400, and M600. M400 group was to receive 400ug of Misoprostol and M600 group was to receive 600ug of Misoprostol immediate after opening the peritoneum. Result: The lowest mean blood loss was seen in the patients who received 600μg in Sublingual Misoprostol group, followed by 400μg Sublingual Misoprostol group. 10.0% case in 400μg and 5.0% case in 600 μg Sublingual Misoprostol group total blood loss was >1000ml. There was significant lower duration of 3rd stage of labour in 600μg dose of Sublingual misoprostol. In 400μg Sublingual Misoprostol 5.0% cases needed one unit and 5.0% cases needed more than one unit blood transfusion. The increased incidence of side effects (like shivering, fever, Abdominal Pain, Nausea &vomiting, Hypotension and Tachycardia) with increase dose of sublingual misoprostol. Conclusion: The lower doses of misoprostol may be as effective as high doses. Clinical applications of low doses of sublingual misoprostol for the prevention of PPH should be further explored by large randomized trials comparing the effectiveness and the safety of low doses of sublingual misoprostol.