Background: Postoperative wound infections significantly impact patient recovery, lengthening hospital stays and increasing healthcare costs. Despite the widespread use of antibiotic prophylaxis, its effectiveness in elective surgeries remains a subject of debate. Methods: A cross-sectional study was conducted involving 140 patients undergoing various elective surgical procedures. Antibiotic prophylaxis efficacy was evaluated by monitoring the incidence of postoperative wound infections within 30 days following surgery. Results: The findings indicated a lower incidence of infections among patients who received antibiotic prophylaxis compared to those who did not, suggesting a significant role of prophylactic antibiotics in preventing postoperative complications. Conclusion: Antibiotic prophylaxis appears to be an effective strategy for reducing the incidence of postoperative wound infections in elective surgical procedures. These results support the continued use of antibiotics as a preventive measure in such settings.