Introduction: Prevalence of hypothyroidism is 2–4% in women in the reproductive age group. Hypothyroidism can affect fertility due to anovulatory cycles, luteal phase defects, hyperprolactinemia, and sex hormone imbalance. Aims and Objectives: To study the prevalence of hypothyroidism in infertile women and the response of treatment for hypothyroidism on infertility. Material & methods: A total of 120 infertile women of Department of Obstetrics and Gynaecology at Government medical college, Jammu & Kashmir were investigated for thyroid stimulating hormone (TSH) and prolactin (PRL). Infertile women with hypothyroidism alone or with associated hyperprolactinemia were given treatment for hypothyroidism with thyroxine 25–150 μg. The statistical analysis was done using IBM SPSS 24.0 software. Results: Of 120 infertile women, 57.5% were hypothyroid (TSH > 4.6 μIU/ml). After the treatment with thyroxine, 37.6% of subclinical hypothyroid women conceived within 6 weeks to 2‑year period. The mean time to conception was 14.56 ± 4.83 months. After treatment for hypothyroidism, 69.5% of infertile women conceived 6 weeks to 1 year. Infertile women with both hypothyroidism and hyperprolactinemia also responded to treatment and their PRL levels returned to normal. Conclusion: Measurement of TSH and PRL should be done at early stage of infertility Check-up rather than straight away going for more costly tests or invasive procedures. Simple, oral hypothyroidism treatment for 3 months to 1 year can be of great benefi t to conceive in otherwise asymptomatic infertile women.