Background: Brachial plexus block is a widely used regional anaesthesia technique for upper limb surgeries. Levobupivacaine and Ropivacaine are two popular local anesthetics used for this purpose.Objectives: To compare the onset and duration of sensory and motor block, duration of analgesia, and side effects of Levobupivacaine 0.5% and Ropivacaine 0.5% in axillary brachial plexus block.Methods: This prospective, randomized, double-blind study included 94 patients (18-60 years, ASA I & II) scheduled for elective below elbow surgeries. Patients were divided into two groups (n=47 each) and received either 20ml of 0.5% Levobupivacaine or 0.5% Ropivacaine. Onset and duration of sensory and motor block, duration of analgesia, and side effects were recorded.Results: Levobupivacaine had a faster onset of sensory block (11.40±2.223 min) compared to Ropivacaine (13.06±2.532 min) (p=0.001). Duration of analgesia and motor block were significantly longer with Levobupivacaine (627.13±66.002 min and 692.77±68.078 min, respectively) compared to Ropivacaine (508.72±60.194 min and 620.00±74.971 min, respectively) (p<0.001). No significant difference was observed in side effects between the groups.Conclusion: Levobupivacaine 0.5% has a faster onset of sensory blockade and longer duration of analgesia and motor block compared to Ropivacaine 0.5% in axillary brachial plexus block.