Background: Pre-eclampsia is a multisystem condition that usually appears in the 20th week of pregnancy. The present study was spot urine protein- creatinine ratio in women with pre-eclampsia in association with 24 hours urinary protein excretion. Methods: 86 women age 18 to 42 years of age was recruited. Parameters such as gestational age (weeks), gravidity and parity, and maternal age, 24-hours urinary protein excretion, random urinary creatinine, random urinary protein-to-creatinine ratio etc. was recorded. Results: The mean 24-hours urinary protein excretion in age group 18-26 years was 2612.3 mg/d, in age group 26-34 years was 1745.1 mg/d and in age group 34-42 years was 1685.2 mg/d. The difference was significant (P< 0.05). The mean protein to creatinine ratio in age group 18-26 years was 3.71 mg/g, in 26-34 years was 3.42 mg/g and in 34-42 years was 1.75 mg/g. The difference was significant (P< 0.05). There was positive correlation between 24- hour urinary protein excretion& random protein to creatinine ratio (r- 0.51, p<0.05). Conclusion: There was relationshipbetween 24-hour urine protein excretion rate and protein/creatinine ratio in random urine specimen of women with preeclampsia.