Objective: To evaluate RDW as a prognostic marker in HFrEF. Materials and Methods: A prospective study was conducted among 50 patients who attended Guru Nanak Dev Hospital, Amritsar in the medicine department for various symptoms and signs related to Heart Failure. The sample population was selected based on a brief history, ECG, and 2echo. RDW was measured using an automated hemolyser. Results: Among 50, 26 were males and 24 were females. Most of the participants in the sample hadan ejection fraction in the range of 20-30%. The sample size with RDW >13.6 was 70% and with ≤13.6, it was30%. Among the participants, samples with higher ejection fractions were associated with good outcomes (NYHA 1 & 2), and those with lower ejection fractions were associated with bad outcomes (NYHA 3 & expired). Sample with higher RDW were associated with bad prognoses and lower RDW with good prognoses. Conclusion: Sample with RDW <13.6, were associated with 100% good outcome. Participants with RDW > 13.6, 48.6% had a good outcome (NYHA1 & 2) and 51.4% had a bad outcome (NYHA 3& expired) with a p-value is highly significant (p = 0.001).Themean RDW was 14.84 and SD 2.25 and 64 % had good outcomes, 36% had bad outcomes.