Aim: To evaluate the efficacy & safety of decompression & stabilization via the posterior approach alone for patients with thoracic & lumbar spine TB. Material and Methods: The present Hospital based retrospective study was conducted in the Department of Orthopedics, CSS Hospital Subharti Medical College, Meerut, Uttar Pradesh, after approval of the research review board, including 24 patients having thoracic & lumbar TB of spine, attending OPD of Department of Orthopedics, after considering the inclusion & exclusion criteria. After enrolment into the study, patient’s information regarding their age, gender & history of present illness was taken & clinical examination was done. Single-stage posterior debridement, decompression & transpedicular screw fixation with Cage or Bone Graftwas performed & outcome measures were evaluated at baseline, preoperatively, & evaluation immediately post operatively, 5th day, before discharge, at 15th day, 1 month, 2 months, 3 months & 6 months. Results: Maximum patients were in age group 18-30 years (36%). Majority of study subjects were females (76%). There was a significant decrease (p<0.01) in mean VAS pain score. There was a significant decrease in lower back pain as reported by patients, after treatment. No loss of kyphosis correction at 6 months follow-up. No complication was encountered in any of the subjects. Conclusion: From present findings it was inferred that both Cage & Bone Graft showed good results with good neurologic recovery, Kyphotic deformity correction & significant improvement in back pain with complete healing & no complications & high success rate, & prevents kyphosis from progressing further. To date, the functional, clinical & radiological outcomes have been positive. Of course, more research with a large increase in sample size & a longer follow-up period will be necessary.