Background-oral and maxillofacial surgical procedures often result in open wounds. A dressing material should cover these wounds to prevent microbial infection, foreign material contamination, wound contracture, and improved healing. The intentions were to make the technique as simple as possible and to determine whether a collagen graft was a suitable dressing material for reconstruction in oral malignancy surgeries. Aim: to evaluate the efficacy of collagen membrane as a biological dressing material for coverage of intra-oral defects with control of bleeding, pain, re-epithelialization and contractures Materials and methods: - all patients admitted under the Department of General Surgery at B.L.D.E.(DU) ’s ShriB.M.Patil Medical College Hospital and Research Centre, Vijayapura. A total of 32 diagnosed patients of carcinoma buccal mucosa who underwent surgical procedures where intra-op synthetic collagen was used for closure of defect were assessed on five parameters, which included 1)Haemostasis 2) Pain 3) Granulation tissue 4) Re-Epithelialization 5) Post-op contracture At the end of pod 3,15, and 1 month and the final assessment at the 3rd month Statistical analysis was done using (S.P.S.S) (version 20) software. Results:Overall, the effectiveness of collagen membrane after three months was found in 29 patients, who had a score of between 8-10, which is very effective, and the remaining three patients had a score between 6-8, which was influential in the remaining cases. Conclusion:The collagen membrane is a specific activator of platelets and causes platelet aggregation over the biomaterial. Thus, it strengthens the clot. Collagen causes chemotaxis, cell aggregation, and adhesion, as well as a release reaction of platelets. Collagen has a chemotactic effect on endothelial cells and fibroblasts; inflammation and pain are significantly reduced. Collagen causes early migration of fibroblasts, leading to good granulation tissue formation. Our results showed good granulation tissue and hameostasis and also ease of using it as a graft and cover material during intra operative procedure.