Background: COPD is a chronic progressive respiratory disease which is a major public health concern. Yoga therapy can have a salutary effect on general and respiratory health improving a person's ability to perform activities of daily living. Methods: A prospective study was conducted with 176 COPD patients following research ethics guidelines. Base line anthropometric, spirometry parameters, SpO2and six minute walking distance was measured. Then the participants were trained with certain yoga (pranayama and breathing exercises) by trained and advised to continue those regularly at their home for one hour each day for 6 months. Participants were asked to revisit after 6 months. Where the same procedures were repeated. The data obtained in pre-yoga and post-yoga was compared by paired t test. Result: After 6 months of yoga, we did not find any significant improvement in lung function parameters, FEV1, FEV1% predicted FVC, FVC % predicted, FEV1/FVC and PEFR. However, the study showed significant improvements in mean 6 minute walk distance(258.47 m ± 33.88 mversus 262.76 m ± 37.09 m; p < 0.01) and SpO2% (92.43 ± 1.31versus 92.59 ± 1.19; p < 0.01). Conclusion: Yoga therapy for a period of 6 months could be used as a component of comprehensive management of COPD.