Background: The present study was conducted for assessing the role of intravenous tranexamic acid in reducing the blood loss during total knee arthroplasty. Materials & methods: A total of 40 osteoarthritis patients were enrolled. Complete demographic and clinical details of all the patients was obtained. The patients were divided in two groups by random allocation as follows: Group A – 20 patients with administration of intravenous tranexamic acid, and Group B- 20 patients who were not administered tranexamic acid. The tourniquet was used in all the cases at appropriate pressure and for the appropriate duration. Tranexamic acid was given 30 mins pre operatively. Patients were assessed for preoperative hemoglobin levels. We evaluated the amount of blood loss occurring during the total knee arthroplasty with and without the administration of tranexamic acid. Results: Mean perioperative blood loss among patients of group A and group B was 275.6 ml and 414.7 ml respectively. Mean postoperative blood loss among patients of group A and group B was 684.9 ml and 911.8 ml respectively. Mean units of blood transfused peri-operatively among patients of group A and group B was 0.38 units and 1.12 units respectively. On comparing, the results were found to be statistically significant. Conclusion: TXA administered intravenously to TKA patients resulted in lower drainage blood loss and lower transfusion frequency and volume. Thus, by preserving a hemodynamically stable state and lowering the likelihood of transfusion-related adverse effects and problems, TXA may contribute to enhancing the general health of patients receiving TKA.