Aim: This study aims to evaluate the efficacy of skin grafting in promoting healing of lower extremity ulcers by assessing healing duration, graft uptake, and complications in a sample of 100 patients. Materials and Methods: The study was conducted during November 2021 to May 2022 at Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar, India. A prospective observational study was conducted in the Department of General Surgery, including 100 patients with lower extremity ulcers. Patients underwent either split-thickness or full-thickness skin grafting. Graft uptake, healing duration, and complications were monitored over a 6-month follow-up period. Data were analyzed using descriptive and inferential statistics. Results: Of the 100 patients, 60% were male and 40% were female, with a mean age of 45.5 ± 12.3 years. Healing times varied, with 40% of patients healing within 4-6 weeks, and 25% showing rapid healing within 4 weeks. Venous ulcers were the most common (40%), followed by diabetic ulcers (30%). The majority of patients (70%) received split-thickness grafts, with 45% achieving 80-90% graft uptake. Complications were minimal, with 15% experiencing infections and 10% facing graft rejection. Conclusion: Skin grafting is an effective treatment for lower extremity ulcers, significantly reducing healing times and achieving high rates of graft uptake. Split-thickness grafts were particularly useful for larger ulcers, while full-thickness grafts were more suitable for complex wounds. Proper postoperative care is essential for optimal outcomes.