Introduction: Labour pain relief is crucial for obstetric care, and epidural analgesia is a common method. Ropivacaine and levobupivacaine, combined with opioids like fentanyl, are frequently used in this context. However, comparative data regarding their efficacy and safety for labor analgesia are limited. This study aims to compare the analgesic efficacy, maternal, and fetal outcomes of epidural analgesia using ropivacaine with fentanyl versus levobupivacaine with fentanyl for labor analgesia. Methods: This prospective, randomized, double-blind, controlled trial involves 200 parturients in active labor. They are randomly allocated into two groups: Group A receiving epidural analgesia with ropivacaine 0.2% with fentanyl 2mcg/ml, and Group B receiving epidural analgesia with levobupivacaine 0.2% with fentanyl 2mcg/ml. Pain relief, onset, and duration of analgesia, maternal satisfaction, mode of delivery, neonatal Apgar scores, and adverse events are assessed. Results: Statistical analysis has been performed using appropriate methods. Preliminary results suggest better pain relief and quicker onset of analgesia with ropivacaine-fentanyl compared to levobupivacaine-fentanyl. However, no significant differences are observed in duration of analgesia, maternal satisfaction, or mode of delivery. Neonatal Apgar scores slightly favor levobupivacaine-fentanyl. Conclusion: Epidural analgesia with ropivacaine-fentanyl provides superior pain relief and faster onset compared to levobupivacaine-fentanyl. Both regimens demonstrate similar durations of analgesia, maternal satisfaction, and mode of delivery. Neonatal outcomes slightly favor levobupivacaine-fentanyl. Careful consideration of these findings alongside patient preferences is essential in optimizing labor pain management.